Structural studies of selected Batten disease proteins (127623)
Tereza Vecerkova
1
2
,
Peter Harrison
1
,
Daniel Clare
1
,
David Sauer
2
,
Andrew Quigley
1
- Diamond Light Source, Didcot, Oxfordshire, United Kingdom
- Centre for Medicines Discovery, University of Oxford, Oxford, United Kingdom
Publish consent withheld
- [1] Wang Y, Zeng W, Lin B, Yao Y, Li C, Hu W, Wu H, Huang J, Zhang M, Xue T, Ren D, Qu L, Cang C. CLN7 is an organellar chloride channel regulating lysosomal function. Sci Adv. 2021 Dec 17;7(51):eabj9608. doi: 10.1126/sciadv.abj9608. Epub 2021 Dec 15. PMID: 34910516; PMCID: PMC8673761.
- [2] Medoh UN, Hims A, Chen JY, Ghoochani A, Nyame K, Dong W, Abu-Remaileh M. The Batten disease gene product CLN5 is the lysosomal bis(monoacylglycero)phosphate synthase. Science. 2023 Sep 15;381(6663):1182-1189. doi: 10.1126/science.adg9288. Epub 2023 Sep 14. PMID: 37708259.
- [3] Sheokand PK, James AM, Jenkins B, K Lysyganicz P, Lacabanne D, King MS, Kunji ERS, Siniossoglou S, Koulman A, Murphy MP, Petkevicius K. TRAM-LAG1-CLN8 family proteins are acyltransferases regulating phospholipid composition. Sci Adv. 2025 Feb 21;11(8):eadr3723. doi: 10.1126/sciadv.adr3723. Epub 2025 Feb 19. PMID: 39970228; PMCID: PMC11838012.